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Direct trains › From Prague

Prague → Brussels

Brussels → Prague ⇄
4 a weekfastest 15h27European SleeperNight train

Direct trains · no change

  • 18:00 → 10:27+1
    European Sleeper 452 Night train
    Praha hlavní nádraží → Brussel-Zuid · via Dresden, Berlin, Amsterdam, The Hague
    16h2714 stops
    Runs: Only Sun 4 Oct, Thu 8 Oct, Sun 18 Oct, Thu 22 Oct, Sun 25 Octopen data confirms only these dates; it may run on othersEuropean Sleeper ↗
  • 18:00 → 10:30+1
    European Sleeper 452 Night train
    Praha hlavní nádraží → Brussel-Zuid · via Dresden, Berlin, Amsterdam, The Hague
    16h3014 stops
    Runs: Only Tue 29 Sep, Tue 6 Oct, Tue 20 Octopen data confirms only these dates; it may run on othersEuropean Sleeper ↗
  • 18:00 → 09:27+1
    European Sleeper 452 Night train
    Praha hlavní nádraží → Brussel-Zuid · via Dresden, Berlin, Amsterdam, The Hague
    15h2710 stops
    Runs: Only Thu 1 Octopen data confirms only these dates; it may run on othersEuropean Sleeper ↗
  • 18:00 → 11:30+1
    European Sleeper 452 Night train
    Praha hlavní nádraží → Brussel-Zuid · via Dresden, Berlin, Amsterdam, The Hague
    17h3013 stops
    Runs: Only Tue 13 Oct, Thu 15 Octopen data confirms only these dates; it may run on othersEuropean Sleeper ↗
  • 18:00 → 13:45+1
    European Sleeper 452 Night train
    Praha hlavní nádraží → Brussel-Zuid · via Dresden, Berlin, Amsterdam, The Hague
    19h4513 stops
    Runs: Only Sun 11 Octopen data confirms only these dates; it may run on othersEuropean Sleeper ↗
  • 18:00 → 12:45+1
    European Sleeper Night train
    Praha hlavní nádraží → Brussel-Zuid · via Dresden, Berlin, Amsterdam, The Hague
    18h4513 stops
    Runs: Only Sun 11 Octopen data confirms only these dates; it may run on othersEuropean Sleeper ↗
  • 18:00 → 14:45+1
    ES 452 Night train
    Praha hlavní nádraží → Brussel-Zuid · via Dresden, Berlin, Amsterdam, The Hague
    20h4511 stops
    Runs: Only Sun 11 Octopen data confirms only these dates; it may run on othersEuropean Sleeper ↗

Local times at each station. From official open timetable data (czptt, de_delfi, de_rv, esleeper) for 28 Sep – 25 Oct 2026; timetables change, so check with the operator before you travel. How we build this.

Door to door vs flying

Overnight: leave 18:00, arrive 09:27

The plane is -12h46 quicker on paper, but the night train uses your night instead of a day and saves a hotel.

Train · fastest direct15h39
  • To Praha hlavní nádraží1 min
  • Before departure10 min
  • European Sleeper 45215h27
  • From Brussel-Zuid1 min
Plane · nonstop PRG–BRU4h25
  • To Václav Havel Airport Prague (PRG)35 min
  • Check-in & security1h30
  • Flight PRG–BRU1h40
  • Landing to exit20 min
  • From BRU20 min

From city centre to city centre unless you pick otherwise. Getting to stations and airports: typical public-transport times (estimates). Airport: check-in & security 1h30 before, 20 min to get out after landing. Flight time is typical for the distance. Nonstop airlines: Brussels Airlines, Smartwings.